Zooming in to acquire micro-reaction: Application of microfluidics on soil microbiome

Microfluidics confers unique advantages in microbiological studies as these devices can accurately replicate the micro- and even nano-scale structures of soil to simulate habitats bacteria. It not only helps us understand spatial distribution bacterial communities (such biofilms), but also provides mechanistic insights into microbial behaviors including chemotaxis horizontal gene transfer (HGT). a feasible means for real-time, situ enables in-depth exploration mechanisms interactions microbiome. This review aims introduce basic principles microfluidic technology summarize recent progress study functions, well biological processes, such chemotaxis, biofilm streamers (BS), quorum sensing (QS), HGT. The challenges future development microfluidics are discussed.